|
KMID : 0603520010060010026
|
|
Journal of Korean Association of Cancer Prevention
2001 Volume.6 No. 1 p.26 ~ p.35
|
|
|
Antitumor Effect and Toxicity of Pine Needle in Mice
|
|
Kil Jeung-Ha
Choi Byung-Tae
Park Kun-Young
|
|
|
Abstract
|
|
|
|
In vivo anticancer effect and toxicity of pine needle was tested using sarcoma-180 cell transplanted mouse. Each group was fed AIN-76 diets containing different levels of powdered pine needle. All mice were sacrificed at 4 weeks followed by the transplantation of sarcoma-180 cells. The growth of tumor induced by sarcoma-180 cells was significantly suppressed in the 10% pine needle added diet group. When the pine needle added diets were fed, glutathione S-transferase activities and glutathione contents in the liver were increased. To determine the levels of toxicity, serum aminotransferase (AST, ALT) activities, blood urea nitrogen (BUN) and creatinine (CRE) levels in the serum were evaluated in the pine needle diets fed mice. Twenty percent of the powdered pine needle added diet group exhibited higher alanine transaminase (ALT) activity and blood urea nitrogen (BUN) level than normal group, suggesting that high level of the pine needle in the diet might cause a toxicity in the liver and kidney of the Balb/c mouse. The distribution of glycogen was improved by the intake of the pine needle in the diet, while the injection of sarcoma-180 cells significantly decreased the glycogen content in the liver. Anticancer effect of 10% pine needle added diet was higher than that of 20% pine needle added. These results indicated that pine needle might have an antitumor activity and its optimal level in the diet was 10% in this experimental system.
|
|
|
KEYWORD
|
|
|
Antitumor, toxicity, Pine needle
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|